"Our study provides critical insight on a paramount issue in HIV research: Why is the body unable to mount an efficient immune response to HIV to prevent transmission?" said one of the researchers Sumit Chanda, professor and director of Sanford Burnham Prebys Medical Discovery Institute (SBP) in the US.
The findings showed that a deficiency in NLRX1 -- an intracellular protein -- reduces the replication of the HIV virus.
It also slows down the power of immune system and promotes immunity to infection.
"Importantly, we were able to show that deficiencies in NLRX1 reduce HIV replication, suggesting that the development of small molecules to modulate the innate immune response may inhibit viral transmission and promote immunity to infection," Chanda added, in the paper published ..